靠近养猪业务作为埃索诺菲尔食管炎的风险因素
Cary C Cotton1, Elizabeth T Jensen2,3, Kate Hoffman4
1From the Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
JPGN reports
|November 30, 2023
概括
居住在猪设施附近可能会增加异性食道炎 (EoE) 的风险. 一项病例控制研究发现,在一个数据集中存在联系,但在另一个数据集中没有,这表明发现取决于所使用的数据源.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 性食道炎 (EoE) 是食道的过敏性炎症性疾病.
- 环境因素越来越多地涉及到 EoE 发展.
- 农业靠近的潜在影响,特别是对猪业的操作,仍在调查中.
研究的目的:
- 调查居住地与允许的猪设施的邻近性与乙性食道炎 (EoE) 风险之间的关联.
主要方法:
- 采用了一种病例控制研究设计.
- 使用了两个不同的数据集:一个来自第三级护理中心,另一个来自大型病理学组.
- 对受试者和猪设施地址的地理编码允许进行近距离和密度计算.
主要成果:
- 在第三级护理数据中,对猪设施的近距离 (<1英里) 和EoE之间观察到一个积极的关联 (aOR=2.56).
- 猪养殖场密度较高 (>10个养殖场/人口普查区) 也与此数据集中的EoE概率增加有关 (aOR=2.76).
- 重要的是,这些关联在病理学组的数据库中没有复制,这表明数据依赖的发现.
结论:
- 虽然在一组数据中,猪业务的近距离和密度显示出与EoE的潜在关联,但在不同数据源中,结果并不一致.
- 需要进一步的研究来证实这些发现,并了解数据集之间观察到的变异性.
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