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降低代谢性骨病负担在肠道功能衰竭中 儿童在家中的父母肠道营养
Andreas Tridimas1,2, Raja Padidela3,4, John Bassett1
1From the Directorate of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK.
JPGN reports
|November 30, 2023
概括
二次性偏甲状腺功能障碍症在接受家庭亲肠道营养的儿科患者中很常见. 一个算法改善了副甲状腺激素 (PTH) 水平,降低了代谢性骨病的风险.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 二次性甲状腺功能增强症是儿童患者经常出现的并发症,需要长期的家庭亲肠道营养.
- 这种情况可以导致显著的代谢性骨病,如果不充分管理.
研究的目的:
- 确定在接受家庭上肠道营养的儿科患者中二次性甲状腺功能障碍症的患病率.
- 评估一种新开发的算法在控制甲状腺前激素 (PTH) 水平方面的有效性.
主要方法:
- 一项服务审查对37名儿科肠道衰竭患者的队列进行了检查,这些患者在约4年内接受了家庭亲肠道营养.
- 在实施算法以管理PTH水平后,对33名患者进行了后续审计.
主要成果:
- 最初,22名 (59%) 患者的PTH水平升高,5名 (14%) 患者的PTH水平持续高.
- 在算法实施后,升高的PTH降至6 (18%),没有患者持续高水平.
结论:
- 升高的PTH是小儿肠道衰竭患者在家庭上肠道营养上常见的发现.
- 优化营养参数,如酸比率和维生素D至关重要.
- 一个算法可以帮助临床医生管理PTH并预防代谢性骨病.
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