越南儿童便抗原测试的消灭率:一个前性的多中心研究
Tu Cam Nguyen1,2, Annie Robert3, Thu Hien Anh Pham4
1From the Department of Gastroenterology, City Children's Hospital, Ho Chi Minh City, Vietnam.
JPGN reports
|November 30, 2023
概括
便抗原测试 (HpSA) 可靠地检测儿童的Helicobacter pylori感染. 然而,根除率较低表明越南需要改进治疗策略.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 诊断的准确性 诊断的准确性
背景情况:
- 杆菌 (H. pylori) 感染是儿童胃肠道问题的常见原因.
- 准确的诊断和治疗疗效的评估对于管理儿童的H. pylori感染至关重要.
研究的目的:
- 为了评估单克隆免疫测试便抗原测试 (HpSA) 对儿童H. pylori感染的诊断性能.
- 用HpSA评估H. pylori根除治疗的有效性.
- 在这个儿科群体中确定HPSA的最佳切割值.
主要方法:
- 一项前性研究涉及394名在胡志明市接受内镜检查的儿童.
- 在治疗前和治疗后收集的便样本上进行了HpSA.
- 基于活检的测试是诊断H.pylori感染的黄金标准.
主要成果:
- 在研究队列中,H. pylori感染很普遍 (78%),常见症状包括表胃疼痛和吐.
- 在HpSA中,诊断准确度高 (88.4%),灵敏度为87.4%,特异性为95.2%.
- 根除率很低 (56.1%的协议, 27.9%的意图治疗),基于性别,营养状况和细菌菌株的变化.
结论:
- 在儿科研究中,HpSA是诊断H. pylori感染和监测消除的可靠工具.
- 在越南儿童中观察到的低根除率强调了优化干预策略的必要性.
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