2名患有短肠综合征的儿童长期服用泰杜格卢提德的胃管多片
Jonathan A Salazar1, Jeffrey D Goldsmith2, Lissette Jimenez1
1From the Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA.
JPGN reports
|November 30, 2023
概括
泰杜格卢提德是治疗短肠综合征的药物,可能会增加小肠多的风险. 这项研究报告了两例儿科患者在一年的特杜格卢提德治疗 (类似葡萄糖类2模拟物) 后出现的状多的病例.
科学领域:
- 胃肠病学 胃肠病学
- 儿科胃肠病学 儿科胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 短肠综合征 (SBS) 是一种以吸收不良为特征的疾病,通常需要肠道适应.
- 泰杜格卢提德是一种类似葡萄糖类2 (GLP-2) 的模拟物,已被批准用于儿科SBS,通过促进表皮细胞增殖来增强肠道适应.
- 虽然有效,但长期的安全性,特别是在聚形成方面,需要持续评估,特别是在儿童群体中.
研究的目的:
- 报告了两例小肠状状增生息肉的病例,这些病例发生在儿童患者中,这些患者接受了teduglutide治疗.
- 为了解Teduglutide在患有SBS的儿童的长期安全性作出贡献.
主要方法:
- 两名患有SBS的儿科患者的回顾性审查.
- 一年后的监测内镜,Teduglutide治疗.
- 切除的息肉的组织病理学检查.
主要成果:
- 两名儿科患者在经过12个月的泰杜格卢提德治疗后,发病了小肠状状超塑性息肉.
- 在开始治疗之前,没有明显的息肉.
- 组织学证实了状细胞增生.
结论:
- 在患有SBS的儿科患者中长期使用teduglutide可能与小肠小息肉形成的风险增加有关.
- 需要进行进一步的研究和长期监测,以充分阐明泰杜格卢类的聚发育风险.
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