在季节性过敏前的allergoid过敏原特异性免疫治疗的第一年,T细胞子集的变化
Manuel Reithofer1,2, Simone Lisa Boell1, Claudia Kitzmueller1
1Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Heliyon
|November 30, 2023
概括
使用修改过敏原的过敏原免疫疗法 (AIT) 显示早期的T辅助细胞增强和降低CD8+T细胞反应. 季节性因素也会影响T细胞在I型过敏治疗期间的激活.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- T细胞生物学T细胞生物学
背景情况:
- 过敏原特异性免疫疗法 (AIT) 是I型过敏的唯一治愈治疗方法,诱导长期的免疫耐受性.
- 化学修饰过敏剂 (allergoids) 在AIT中使用,通常采用季前应用时间表.
- 以前的研究强调了AIT的临床疗效和对抗体反应的影响,但T细胞动态需要进一步调查.
研究的目的:
- 调查T细胞子集在I型过敏患者的前季节性AIT与过敏症患者的动态变化.
- 为了将T细胞子集的变化与已建立的保护性抗体反应相关联.
- 探索气象季节在治疗期间对T细胞激活概况的影响.
主要方法:
- 长度观察性研究监测从接受过敏性AIT的患者的外周血液单核细胞 (PBMCs).
- 对CD4+和CD8+T细胞子集的流细胞计分析,包括T毛囊辅助细胞 (Tfh) 和T毛囊调节细胞 (Tfc).
- 在整个治疗过程中评估T细胞对过敏原刺激的反应.
主要成果:
- 在AIT治疗4个月后观察到过敏性T辅助 (Th) 细胞的短暂增加和Tfh和Tfc细胞的轻微Th2偏差.
- 在治疗期间, CD8+ T 细胞对过敏原刺激的反应显著下降.
- 发现气象季节会影响Tfh和Tfc细胞的激活概况.
结论:
- 这项研究提供了第一次全面分析T细胞亚群动态在空气中的过敏原的allergoid AIT期间.
- 结果与传统的AIT一致,显示出初始的Th2反应,尽管在过敏药物或降低维持剂量时可能不那么明显.
- 观察到的T细胞变化表明,在过敏原AIT期间发生的复杂免疫调节,受到治疗和环境因素的影响.
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