一个系统的审查和对艾滋病毒感染和多药耐药结核病之间的相关性进行元分析
Yulong Song1, Qian Jin1, Jihai Qiu1
1Department of Infectious Disease,Taizhou Municipal Hospital, Tai Zhou City, Zhejiang Province, 318000, China.
Heliyon
|November 30, 2023
概括
艾滋病毒感染显著增加了多药耐药结核病 (MDR-TB) 的风险. 这一元分析证实了正相关性,强调了对艾滋病毒阳性个体的早期检测和有效控制计划的需要.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 艾滋病毒阳性个体的多药耐药结核病 (MDR-TB) 构成了全球重大卫生挑战.
- 相互矛盾的研究结果需要对艾滋病毒和MDR-TB之间的关联进行全面审查.
- 评估艾滋病毒对MDR-TB的全球影响对于公共卫生战略至关重要.
研究的目的:
- 对艾滋病毒感染与MDR-TB之间的关联进行全面的文献审查.
- 评估艾滋病毒对MDR-TB的流行和风险的全球影响.
- 综合现有研究以澄清艾滋病毒和MDR-TB之间的相关性.
主要方法:
- 对2000年1月至2023年3月期间发表的研究进行了系统的元分析.
- 搜索的数据库包括PubMed,Scopus,谷歌学者和科学直接.
- 用一个随机效应模型来计算聚合赔率比率,使用Egger和Begg的测试来评估出版偏差.
主要成果:
- 最终分析包括了15项涉及9667名患者的研究.
- 在HIV/AIDS和MDR-TB之间发现了显著的正相关性,赔率比为2.78 (95%CI:1.07-7.20).
- 实质性的异质性 (I2 = 99%) 表明使用随机效应模型,证实了积极的关联.
结论:
- 艾滋病毒感染显然增加了患MDR-TB的风险.
- 这些发现强调,迫切需要在艾滋病毒阳性患者中早期发现病例.
- 有效的感染控制计划和质量保证的诊断对于在这个人群中管理MDR-TB至关重要.
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