孕前母亲的肥胖会影响早产婴儿中未经切割的带 (uncinate fasciculus) 白质道
Joo Young Lee1, Hyun Ju Lee2,3, Yong Hun Jang1
1Department of Translational Medicine, Hanyang University Graduate School of Biomedical Science and Engineering, Seoul, Republic of Korea.
Frontiers in pediatrics
|November 30, 2023
概括
怀孕期间母亲的肥胖与早产婴儿的大脑发育的改变有关. 具体来说,较高的母体体重指数 (BMI) 与白质微观结构的变化有关,可能会影响神经发育结果.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 孕前母亲的肥胖与后代的不良神经发育结果有关.
- 越来越多地认识到母亲肥胖对胎儿和新生儿大脑发育的影响.
- 肥胖母亲早产婴儿的大脑微观结构的变化尚未得到充分理解.
研究的目的:
- 用扩散张力成像 (DTI) 来研究早产婴儿的脑部微观结构差异,这些婴儿的母亲在怀孕前患有肥胖症.
- 检测暴露于母亲肥胖的早产婴儿的大脑体积和白质 (WM) 区域的变化.
主要方法:
- 扩散张力成像 (DTI) 用于评估32名早产婴儿的脑部微观结构,这些婴儿的年龄相当于预产期 (TEA).
- 婴儿根据孕前母亲的体重指数 (BMI) 进行分类:正常与高.
- 分析了主要白质道的大脑体积和DTI参数,并在各组之间进行了比较.
主要成果:
- 患有高BMI的母亲的早产婴儿表现出皮质灰质体积增加和白质体积减少.
- 与正常BMI的婴儿相比,与高BMI的母亲分娩的婴儿的未切割囊 (UNC) 中观察到明显较低的轴向扩散率.
结论:
- 孕产妇的肥胖会影响早产儿的围产期大脑发育,即使没有明显的脑损伤.
- 在肥胖母亲的后代中,改变了UNC白质微观结构可能对语言和社会情感发展产生影响.
- 这些发现凸显了母亲肥胖对后代大脑发育轨迹的有害影响.
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