在COVID-19患者中AF和住院死亡率
Irum D Kotadia1, Maria Dias1, Caroline Roney1
1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Heart rhythm O2
|November 30, 2023
概括
新发性心房动 (AF) 在住院COVID-19患者中显著增加死亡风险. 然而,先前存在的AF没有显示出与不良结果的独立关联,强调需要监测新的AF病例.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 关于新发性心房动 (AF) 与COVID-19患者的不良结果之间的关联,存在相互矛盾的数据.
- 这项研究旨在澄清新发性AF与先前存在的AF对COVID-19临床结果的独立影响.
- 它代表了迄今为止最大的数据集,手动策划,比较突节律,先前存在的AF和新出现的AF群体的结果.
研究的目的:
- 评估COVID-19患者的患者结局,根据鼻节律,先前存在的AF和新发作的AF分层.
- 在COVID-19感染的个体中确定新发性AF的预测因子.
- 确定新发性AF是否是住院COVID-19患者死亡率的独立预测因素.
主要方法:
- 一个单一中心的回顾性研究包括1241名在2020年3月至9月期间入院的COVID-19确诊患者.
- 手动图表审查收集了人口统计,病史和临床结果数据.
- 倾向性得分匹配用于AF组与非AF对照组之间的调整比较.
主要成果:
- 在1241名患者中,94名 (7.6%) 患有先前存在的AF,42名 (3.4%) 患有新发的AF.
- 新发性AF与与非AF组相比,在 (OR 3.58) 和 (OR 2.80) 倾向性得分匹配之前 (OR 3.58) 和之后 (OR 2.80) 的住院死亡率明显增加有关.
- 预先存在的AF没有显示出与在医院死亡率的独立关联 (OR 1.13).
结论:
- 新发性AF,但不是先前存在的AF,独立地与住院COVID-19患者的死亡率增加有关.
- 这一发现强调了警监测COVID-19患者新发性AF的重要性.
- 需要进行进一步的研究,以阐明COVID-19的背景下新发性AF和不良临床结果之间的机制联系.
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