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在患有喉癌的患者中,血小板聚合功能的预后值

Minghua Li¹, Jiawei Gui¹, Hao Wang²

¹Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, People's Republic of China.

International journal of general medicine

|November 30, 2023

概括

升高的血小板聚合功能,特别是腺二酸盐诱导的光传导度聚合度 (ADP诱导的LTA) >15.1,与喉癌患者的不良结果有关. 这一发现表明,血小板聚合功能可能成为这种恶性瘤的新预后指标.

科学领域:

在瘤学瘤学.
血液学血液学血液学
病理学病理学病理学

背景情况:

喉癌是癌症相关死亡的重要原因,其特点是高复发率和转移率.
已知血小板,特别是激活的血小板,可以增强瘤细胞的增殖,入侵和转移.
喉癌中血小板聚合功能的预后价值尚未得到充分确立.

研究的目的:

为了研究血小板聚合功能在喉癌中的预测意义.
为了确定腺二酸盐诱导的光传导度聚合度 (ADP诱导的LTA) 是否可以预测患者的结果.

主要方法:

对2015年1月至2016年12月期间确诊的203名喉癌患者的回顾性分析.
将患者分为两类:低 (ADP诱导的LTA≤15.1) 和高 (ADP诱导的LTA>15.1) 的血小板聚合功能组.
使用卡普兰-梅尔曲线和考克斯回归分析评估的预后意义.

主要成果:

低ADP诱导的LTA队列表现出较高的淋巴细胞数量和较低的血小板与淋巴细胞比率 (PLR),ADP诱导的LTA和IL-6 (IL-6).
增加的ADP诱导的LTA独立地与较差的5年整体生存率相关 (危险比,1.212;P <0.001).

结论:

患有高ADP诱导的LTA (>15.1) 的患者表现明显较差.
血小板聚合功能,特别是ADP诱导的升高的LTA,显示出作为喉癌的新预后指标的潜力.

关键词:

这是一种炎症炎症炎症炎症.喉癌 (Laryngeal Carcinoma) 是一种喉癌.总的说来,整体存活率是很高的.血小板聚合功能的功能.血小板与淋巴细胞的比率.

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