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在中国南部的人口中,阿波利波蛋白E基因多态与2型糖尿病病的关联

Caiyan Gan^1,2,3, Yinmei Zhang^1,2,3, Xianyan Zhang⁴

¹Research Experimental Center, Meizhou People's Hospital, Meizhou, People's Republic of China.

International journal of general medicine

|November 30, 2023

概括

无脂蛋白E (APOE) ε2等位基因和E2/E3基因型增加了中国南部糖尿病病 (DN) 的风险. 相反,APOE ε3等位基因和E3/E3基因型似乎对DN发育有保护作用.

科学领域:

遗传学遗传学是一个
腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.

背景情况:

常见的阿波利波蛋白E (APOE) 基因多态 (rs429358,rs7412) 定义了等位基因 (ɛ2,ɛ3,ɛ4) 和基因型.
APOE多态与糖尿病病 (DN) 的关联需要区域性澄清.
这项研究调查了APOE在中国南部DN敏感性和脂质特征中的作用.

研究的目的:

为了确定APOE基因多态和DN风险之间的关联.
分析APOE基因型对中国南部人口血清脂质概况的影响.
确定影响DN易受性的特定APOE等位基因和基因型.

主要方法:

病例控制研究涉及306名DN患者和483名2型糖尿病控制人.
使用聚合酶链反应 (PCR) 微阵列基因芯片分析的APOE基因多态性.
对所有参与者收集的临床数据和血清脂质概况.

主要成果:

在DN患者和对照人群之间,性别,SBP,高血压,高尿血,UTP,TG和HDL-C的显著差异.
在DN患者中观察到APOE ε2等位基因和E2/E3基因型的更高频率 (p < 0.001).
APOE ε2等位基因和E2/E3基因型被确定为DN的独立风险因素; ε3等位基因和E3/E3基因型显示有保护作用.

结论:

在中国南部的哈卡人群中,APOE多态与DN相关.
APOE ε2等位基因和E2/E3基因型与DN风险增加有关.
APOE ε3等位基因和E3/E3基因型与DN的风险降低有关.

关键词:

亚脂蛋白 E 是一种阿波利波蛋白.糖尿病性脏病糖尿病性脏病基因多形态的多态化中国南部的中国.

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