鼻内用德克斯米德提米丁可以改善慢性失眠的老年患者的术后睡眠质量:一项随机双盲对照试验
Jinghan Wu1,2, Xingyang Liu1, Chunyan Ye1
1Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in pharmacology
|November 30, 2023
概括
鼻内用德克斯梅德托米丁 (DEX) 在手术后慢性失眠的老年人中显著改善了术后睡眠质量. 这种治疗改善了睡眠指标,并减少了失眠的严重程度,没有任何不良影响.
科学领域:
- 麻醉学 麻醉学
- 睡眠医学 睡眠医学
- 老年病的医生 老年病的医生
背景情况:
- 在老年患者中,特别是慢性失眠患者中,术后睡眠障碍很常见.
- 老年手术患者的慢性失眠会对康复产生负面影响,并增加并发症的风险.
- 需要有效和安全的干预措施来管理这一脆弱人群的术后睡眠质量.
研究的目的:
- 为了研究内德克斯梅托米丁 (DEX) 在改善手术后睡眠质量的有效性.
- 评估DEX对慢性失眠的老年患者主观和客观睡眠参数的影响.
- 在这个患者群体中评估鼻内DEX的安全性.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及110名老年患者 (65岁以上) 患有慢性失眠,接受部/膝盖关节整形手术.
- 参与者在手术后每天晚上接受内德克斯梅德托米丁 (2.0μg/kg) 或液安慰剂,直到下院.
- 睡眠质量通过使用利兹睡眠评估问卷 (LSEQ),Acti-graph,匹兹堡睡眠质量指数 (PSQI) 和失眠严重程度指数 (ISI) 来评估.
主要成果:
- 与安慰剂相比,鼻内DEX显著改善了"入睡"和"睡眠质量"的LSEQ分数 (p < 0.0001).
- 客观的睡眠测量,包括总睡眠时间 (TST),睡眠开始延迟 (SOL) 和睡眠效率 (SE),显示DEX显著改善 (p < 0.0001).
- 德克斯治疗导致PSQI和ISI得分显著降低 (p < 0.001),没有报告的不良事件.
结论:
- 鼻内用德克斯梅托米丁是一种有效的治疗方法,可以改善慢性失眠的老年手术患者的手术后睡眠质量.
- 德克斯可以提高主观和客观的睡眠参数,从而提高睡眠质量,减少失眠的严重程度.
- 内注射DEX似乎是安全的,并且在这个人群中耐受良好,提供了一个有前途的治疗选择.
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