西班牙抗抑郁药不服药造成的药物经济负担
Eduardo Gutiérrez-Abejón1,2,3,4, M Aránzazu Pedrosa-Naudín3, Diego Fernández-Lázaro5,6
1Pharmacological Big Data Laboratory, Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Frontiers in pharmacology
|November 30, 2023
概括
对抗抑郁药物的不坚持显著影响患者的结果,并造成大量成本,近20%的患者不坚持. 干预对于改善抗抑郁药治疗的临床结果和经济效率至关重要.
科学领域:
- 药物经济学 药物经济学
- 公共卫生 公共卫生
- 临床药房 临床药房
背景情况:
- 抗抑郁药不坚持与不良健康结果,增加死亡率和更高的医疗费用有关.
- 了解与抗抑郁药治疗和不服药相关的经济负担对于医疗管理至关重要.
研究的目的:
- 评估基于人群的队列中的抗抑郁药不服药率.
- 分析2021年抗抑郁药治疗和不服药的经济影响.
主要方法:
- 一项基于人口的注册研究利用药物占有率 (MPR) 来衡量不遵守,将MPR低于80%的患者定义为不遵守者.
- 收集和分析了2021年关于抗抑郁药费用和患者支出的经济数据.
主要成果:
- 在2021年,246,718名患者因抗抑郁药费用支付了2900万欧元,平均每年每名患者的费用为70.08欧元.
- 近20%的患者是不坚持,为总抗抑郁药费用贡献了390万欧元 (13.30%).
- 特定的抗抑郁药物,如fluoxetine和fluvoxamine显示了超过20%的不坚持率,而venlafaxine和citalopram的不坚持率低于15%.
结论:
- 减少对抗抑郁药物的不坚持对于提高临床和经济结果至关重要.
- 医疗保健提供者应考虑个体抗抑郁药不坚持率和成本,利用诸如药物占有率等工具进行早期检测和干预.
- 迫切需要实施标准化措施和早期检测指标,以解决抗抑郁药不服药问题.
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