肠道微生物在与代谢相关的脂肪肝疾病中的作用
1Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan.
Tzu chi medical journal
|November 30, 2023
概括
肠道微生物及其代谢物显著影响代谢相关脂肪肝疾病 (MAFLD). 微生物代谢物如SCFA,胆汁酸和酸代谢物影响肠道屏障功能和炎症,为MAFLD提供治疗潜力.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是一种普遍存在的慢性肝病.
- 肠道失生症通过增加肠道透性和全身炎症,有助于MAFLD的发病.
- 微生物代谢物在调节与MAFLD相关的宿主生理学方面发挥着至关重要的作用.
研究的目的:
- 审查微生物代谢物在MAFLD发展中的作用.
- 探索短链脂肪酸 (SCFA),胆汁酸和托代谢物如何影响MAFLD.
- 确定具有对MAFLD治疗潜力的细菌属.
主要方法:
- 文献综述侧重于微生物代谢物和MAFLD.
- 分析SCFA对肠道屏障功能和炎症的影响.
- 检查肠道微生物及其信号通路对胆汁酸的改变.
- 研究托代谢物生产和MAFLD相关性.
主要成果:
- 一般来说,SCFA具有抗炎作用,并改善肠道屏障的完整性.
- 肠道微生物修改胆汁酸特征,影响宿主受体,如FXR和TGR5.5.
- 三的代谢物 (基努伦因,血,-3-) 涉及到MAFLD的发病.
- 确定了参与代谢产生的特定细菌系.
结论:
- 微生物代谢物是MAFLD发展的关键媒介.
- 准微生物代谢物和肠道微生物群为MAFLD提供了一个有希望的治疗策略.
- 在临床前模型中,某些细菌显示出对MAFLD缓解的潜力.
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