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与瘤相关的巨细胞:瘤微环境的有效参与者
Udit Basak1, Tania Sarkar1, Sumon Mukherjee1
1Division of Molecular Medicine, Bose Institute, Kolkata, India.
Frontiers in immunology
|November 30, 2023
概括
与瘤相关的巨细胞 (TAMs) 通过转移到亲瘤M2状态来促进癌症,从而阻碍免疫治疗. 针对这种瘤-TAM交叉对有效的癌症治疗至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 癌症的进展涉及瘤微环境 (TME) 内的复杂相互作用.
- 瘤相关巨细胞 (TAMs) 是TME中的关键免疫细胞,具有M1 (抗瘤) 和M2 (前瘤) 亚型.
- 瘤操纵TME有利于M2TAMs,促进癌症生长和免疫逃避.
研究的目的:
- 审查TAMs驱动癌症进展和免疫治疗失败的机制.
- 阐明M2 TAMs在支持瘤生长,转移和癌症干细胞 (CSC) 出现中的作用.
- 提出针对癌细胞,CSC和TAM的整体治疗策略.
主要方法:
- 文献综述侧重于瘤微环境相互作用,TAM两极化和免疫疗法耐药性.
- 对TAM和癌细胞 (包括CSCs) 之间的交叉分析.
- 综合当前的理解,以确定治疗点.
主要成果:
- M2 TAMs促进癌细胞的增殖,血管新生,上皮细胞转移到介质细胞,以及转移.
- TAMs有助于癌症干细胞 (CSC) 的发展和存活.
- 在TME中M2 TAM偏差创造了一个免疫抑制的环境,导致免疫治疗失败.
结论:
- 准前瘤M2TAM表型及其与癌细胞和CSC交叉交谈对于克服免疫疗法耐药性至关重要.
- 一种多方位的治疗方法同时针对癌细胞,CSC和TAM,为有效的癌症治疗提供了一个有希望的策略.
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