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EBF1,MYO6和CALR表达水平预测了扩散大B细胞淋巴瘤的治疗反应

Alice Turdo1, Miriam Gaggianesi2, Caterina D'Accardo1

  • 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.

Frontiers in immunology
|November 30, 2023
PubMed
概括

识别基因表达特征可以预测扩散性大B细胞淋巴瘤 (DLBCL) 治疗反应. 像EBF1,MYO6和CALR这样的特定基因表明,在接受R-CHOP治疗的DLBCL患者的生存率更差.

关键词:
在R-CHOP中,使用R-CHOP.应答的生物标志物扩散大的B细胞淋巴瘤.年长的病人,老年患者.基因表达的签名 基因表达的签名治疗耐药性 治疗耐药性

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...