在青少年中高口服携带多药耐药格拉姆阴性细菌:SOPKARD-Junior研究
Marta Katkowska1, Katarzyna Garbacz1, Ewa Kwapisz1
1Department of Oral Microbiology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Frontiers in cellular and infection microbiology
|November 30, 2023
概括
在健康的青少年中发现了多药耐药格拉姆阴性细菌 (GNB) 的高口腔殖民率. 产生扩展光谱β-乳糖酶 (ESBL) 的GNB与呼吸系统问题有关,突出显示需要进一步研究.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 青少年健康 青少年健康
背景情况:
- 在青少年中,抗菌素耐药细菌对口腔的殖民性尚不清楚.
- 由于其潜在的致病性和耐药性,格拉姆阴性细菌 (GNB) 是一个令人担忧的问题.
- 多种药物耐药性 (MDR),包括ESBL和卡巴酶生产,需要在这个人口群体中进行调查.
研究的目的:
- 在健康的青少年中确定GNB口腔殖民的流行率.
- 评估这些GNB菌株的多药耐药性模式.
- 确定与GNB殖民和抵抗相关的风险因素,包括ESBL和卡巴酶生产.
主要方法:
- 在波兰索波特,从182名青少年 (13-14岁) 收集的口腔样本.
- 使用MALDI-TOF MS进行细菌鉴定;通过磁盘扩散进行抗菌素耐药性查.
- 使用NG-Test CARBA-5检测碳酶;对人口统计和临床数据的统计分析.
主要成果:
- 37.4%的青少年显示口腔GNB殖民,其中27.5%携带多药耐药菌株 (MDR-GNB).
- 主导的属包括Enterobacter,Pseudomonas和Serratia. 这三种类型是主要的. 观察到对安培西林,塞夫塔齐迪姆,美罗和胺素的高耐药率.
- 在7.4%的GNB菌株中发现扩展谱β-乳糖酶 (ESBL) 生产,与复发性呼吸道感染有显著的关联.
结论:
- 在健康的青少年中存在显著的MDR-GNB口服携带.
- 产生ESBL的GNB殖民与这个年龄组的呼吸道感染有关.
- 进一步的研究至关重要,以了解GNB口腔殖民在不同感染和抗生素耐药性获得中的作用.
关键词:
肠道细菌 (Enterobacter) 是一个细菌.格拉姆阴性细菌 (GNB) 是一种伪omonas 是一个类型的.塞拉蒂亚塞拉蒂亚是什么意思扩展光谱β-乳酸酶 (ESBL) 的使用多药耐药性 (MDR) 是指多药耐药性.口腔载体口腔载体是指口腔载体.口头殖民化的口头殖民.更多相关视频
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