美国成年人脂肪和炎症之间的积极关联:一个横截面研究
Koya Ferrell1, Isaiah Brown1, Abel Amare1
1Division of Intramural Research, National Institute on Minority Health and Health Disparities, Bethesda, Maryland, USA.
Clinical obesity
|November 30, 2023
概括
腹部直径 (SAD) 测量的内脏脂肪独立地与较高的炎症有关,由累积炎症指数 (CII) 表示. 这种关联适用于不同的糖尿病状态,突出了与肥胖相关的关键炎症过程.
科学领域:
- 肥胖和新陈代谢 肥胖和新陈代谢
- 炎症和免疫学 炎症和免疫学
- 流行病学和公共卫生.
背景情况:
- 与肥胖相关的炎症是一个复杂的过程,需要确定可靠的生物标志物.
- 内脏脂肪,肥胖的一个关键组成部分,与炎症标志物增加有关.
- 开发有效的流行病学查工具用于肥胖需要了解炎症和内脏脂肪.
研究的目的:
- 为了检查炎症和内脏脂肪之间的关联在美国成年人的一个大型,全国代表性样本中.
- 为了确定这种关联是否受到糖尿病状况的影响.
- 确定肥胖相关炎症过程的潜在生物标志物.
主要方法:
- 使用线性回归模型进行回顾性观察研究.
- 对10655名美国成年人全国代表性样本的分析.
- 通过累积炎症指数 (CII) 评估的炎症,使用白细胞比率和尿酸.
- 腹部肥胖度是用腰腹部直径 (SAD) 来衡量的.
主要成果:
- 在腰腹直径 (SAD) 和累积炎症指数 (CII) 之间观察到正相关性.
- 对于每一个单元增加的SAD,CII增加了0.12在正常血糖,0.09在糖尿病前期,和0.10在糖尿病成年人.
- SAD和CII之间的关联独立于糖尿病状况.
结论:
- 增加的内脏脂肪独立地与增加的内脏相关炎症有关.
- 这些发现支持内脏脂肪的作用作为系统性炎症的重要贡献者.
- 需要进一步的研究来描述与肥胖相关的炎症媒介及其在糖尿病等慢性疾病中的作用.
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