与艾滋病毒感染相关的Mpox (麻疹) 风险和死亡率:尼日利亚的国家病例控制研究
Adesola Yinka-Ogunleye1,2, Mahmood Dalhat3,4, Afolabi Akinpelu5
1Department of Surveillance and Epidemiology, Nigeria Centre for Disease Control, Abuja, Nigeria adesola.yinka-ogunleye.20@ucl.ac.uk.
BMJ global health
|November 30, 2023
概括
人类免疫缺陷病毒 (HIV) 同感染显著增加了mopox获得和死亡的风险. 年轻年龄也增加了mpox病例的死亡风险,突出了针对性干预的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 最近的mopox疫情显示疾病特征发生变化和更广泛的传播.
- 了解共感染对于管理mopox复发至关重要.
研究的目的:
- 调查人类免疫缺陷病毒 (HIV) 和性传播感染 (STIs) 在尼日利亚mopox疫情中的共同感染的作用.
- 为国家和全球Mopox应对策略提供信息.
主要方法:
- 进行了一项全国性的描述性和病例控制研究.
- 马波克斯病例与来自全国艾滋病毒/艾滋病调查的对照病例进行了匹配.
- 后勤回归分析了艾滋病毒和mopox风险/死亡率之间的关联.
主要成果:
- 在确诊的mopox病例中,有27.9%的患者同时感染了HIV.
- 同时感染艾滋病毒与增加的mopox风险 (OR 45) 和死亡率 (aOR 13.66) 有着强烈的关联.
- 年轻年龄也与较高的mopox死亡率 (aOR 0.90) 有关.
结论:
- 艾滋病毒共感染是MPOX感染和死亡的重要风险因素.
- 在mopox爆发期间,儿童和艾滋病毒感染者需要有针对性的关注.
- 高STI患病率表明,与高风险性行为存在潜在联系.
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