心理健康障碍中的安慰剂效应:总体审查的协议
Nathan Tm Huneke1,2, Jay Amin3,2, David S Baldwin3,2,4
1Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK n.huneke@soton.ac.uk.
BMJ open
|November 30, 2023
概括
本综合性综述综合了心理健康临床试验中对安慰剂反应的研究. 了解安慰剂效应对于设计更好的试验和开发心理健康障碍有效治疗至关重要.
科学领域:
- 精神病学和临床心理学
- 证据综合 证据综合
- 临床试验方法论 临床试验方法论
背景情况:
- 心理健康障碍的患病率很高,具有重大的社会经济影响.
- 随机对照试验 (RCT) 中安慰剂反应可能是相当大的,复杂的治疗效果解释.
- 了解影响安慰剂反应的因素对于改善临床试验设计至关重要.
研究的目的:
- 对心理健康障碍中安慰剂反应进行系统性审查和元分析进行总体审查.
- 综合不同心理健康状况中安慰剂反应的效果大小.
- 识别和总结心理健康RCT中安慰剂反应的预测因素.
主要方法:
- 在主要数据库 (Medline,PsycINFO,EMBASE,Web of Knowledge) 中系统地搜索相关的系统审查和元分析.
- 摘要和完整文本的对选用于数据提取.
- 对安慰剂效应大小变化和跨疾病预测因子的定性检查.
- 使用AMSTAR-2工具进行偏差风险评估.
主要成果:
- 审查将质量检查安慰剂效应大小在精神健康障碍中如何变化.
- 它还将从定性上总结确定了增加安慰剂反应的预测因素.
- 将确定当前知识的差距,以产生未来研究假设.
结论:
- 这一综合性综述将提供心理健康研究中安慰剂反应的全面综合.
- 结果将为未来临床试验的设计提供信息,以更好地检测活性治疗效应.
- 这项研究旨在进一步了解精神病学研究中的安慰剂现象.
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