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接种疫苗的儿科固体器官移植接收者的Omicron感染

John McAteer^1,2, Divya D Kalluri³, Rivka R Abedon³

¹Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Journal of the Pediatric Infectious Diseases Society

|November 30, 2023

概括

接种疫苗的儿科固体器官移植接受者 (pSOTRs) 经常经历SARS-CoV-2 Omicron感染. 尽管抗体反应很强,但中和能力很差,尽管感染仍然温和.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
儿科医学儿科医学

背景情况:

固体器官移植接受者 (SOTRs) 免疫力受损,增加感染风险.
疫苗接种对SOTRs至关重要,但其对新型SARS-CoV-2变种的有效性令人担忧.

研究的目的:

在接种疫苗的小儿SOTR中,评估在Omicron波期间SARS-CoV-2感染的频率和严重程度.
评估这一群体中对Omicron亚变体的抗体反应和中和能力之间的相关性.

主要方法:

对一组接种疫苗的儿科SOTRs进行了回顾性分析.
监测SARS-CoV-2感染和评估抗受体结合域 (anti-RBD) 抗体水平.

主要成果:

在Omicron期间,在接种疫苗的pSOTR中观察到频繁突破的SARS-CoV-2感染.
强大的抗RBD抗体反应并不能保证保护,这表明对Omicron亚变体的中和能力较差.
突破性感染通常具有有限的临床严重性.

结论:

接种疫苗的pSOTRs仍然容易感染SARS-CoV-2 Omicron感染.
目前的疫苗诱导抗体反应可能无法完全中和pSOTRs中的Omicron亚型.
持续的监测和潜在的助推策略对于这个脆弱的人群来说很重要.

关键词:

在 COVID-19 疫情中,这种Omicron变异是什么?突破性的突破突破性的突破接种mRNA疫苗的方法儿科儿科儿科儿科实体器官移植实体器官移植

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