在妊娠糖尿病中缺陷的内脏脂肪组织适应 妊娠糖尿病
Colm J McElwain1, Samprikta Manna2, Andrea Musumeci1
1Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, Cork T12XF62, Ireland.
The Journal of clinical endocrinology and metabolism
|November 30, 2023
概括
肥胖怀孕的孕期糖尿病 (GDM) 涉及到内脏脂肪重塑不良和胰岛素信号功能障碍. 这会阻碍新陈代谢健康,并在怀孕期间导致胰岛素抵抗.
科学领域:
- 产科和妇科 产科和妇科
- 代谢障碍 代谢障碍 代谢障碍
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 孕期糖尿病 (GDM) 是一种影响葡萄糖代谢和全身健康的妊娠并发症.
- 内脏脂肪组织 (VAT) 在GDM病理生理学中发挥作用.
- 肥胖会加剧GDM并影响母亲的结果.
研究的目的:
- 为了研究内脏脂肪组织 (VAT) 作为GDM的贡献者.
- 为了确定肥胖和GDM对母亲结果的影响.
- 阐明与GDM相关的VAT和胎盘中的分子机制.
主要方法:
- 在56名无卵性妇女 (30名正常耐葡萄糖,26名GDM) 的截面研究中.
- 参与者被分类为非肥胖 (BMI <30 kg/m2) 或肥胖 (BMI ≥30 kg/m2) 的参与者.
- 分析代谢标记物,增值税形态,增值税中的胰岛素信号和胎盘因素.
主要成果:
- GDM参与者表现出高胰岛素血症和更高的胰岛素耐药性 (HOMA-IR).
- 肥胖的GDM参与者表现出VAT脂肪细胞过度增殖和改变的胰岛素信号 (较低的IRS-2,较高的p-IRS-1).
- 在GDM肥胖患者中升高的瘦素和胎盘脂素;在GDM非肥胖患者中改变的脂素/脂素.
结论:
- 肥胖孕妇的GDM与不良的增值税改造和受损的分子信号传递有关.
- 这些增值税变化在很大程度上导致了GDM的胰岛素抵抗.
- 功能障碍的增值税信号会对怀孕期间的代谢健康产生负面影响.
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