非糖尿病非酒精性脂肪肝疾病中的关节缩压指数:一个病例对照研究
Said Taharboucht1, Rachida Guermaz2, Mansour Brouri2
1Service de médecine interne, CHU de Douera, Alger, Algeria.
Journal de medecine vasculaire
|November 30, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 与较高的外围动脉疾病 (PAD) 患病率有关,这是由低脚-手臂压力指数 (ABPI) 表明的. 这表明NAFLD患者面临心血管风险增加.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 血管医学 血管医学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 的死亡率主要与心血管疾病有关,而不是肝脏并发症.
- 周围动脉疾病 (PAD) 是整体心血管风险的重要指标.
- 脚-手臂压力指数 (ABPI) 作为PAD的有价值的查工具.
研究的目的:
- 调查NAFLD和ABPI之间的关联.
- 评估ABPI作为NAFLD患者心血管风险标志物的实用性.
主要方法:
- 一项前性,性别和年龄匹配的病例控制研究,涉及213名NAFLD患者和213名对照患者 (30-70岁,非糖尿病).
- 通过超声波诊断出肝肥胖症;使用多普勒测量ABPI.
- 此外,还进行了带关节脉冲波速率 (CfPWV) 和上大动脉干的动脉超声波.
主要成果:
- 与对照组相比,NAFLD患者的低ABPI (<0.9) 患病率明显高 (8.9%对2.3%,P=0.003).
- 代谢综合征在NAFLD组中更为普遍.
- PAD与NAFLD显著相关 (OR=4.0),独立预测因素包括夜间缩血压,吸烟,大腿周长和女性性别.
结论:
- 在NAFLD和低ABPI之间存在显著的关联.
- 在NAFLD患者的低ABPI反映了血管风险概况的升高.
- 测量ABPI是评估NAFLD心血管风险的一个有价值的工具.
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