双功能阿斯塔桑宏分子纳米载体,可缓解德克斯硫酸诱导的炎症性肠病
Xiumin Zhang1, Wentao Su1, Yannan Chen1
1Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian 116034, Liaoning, China; State Key Lab of Marine Food Processing & Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
新的双重营养纳米载体有效地提供阿斯素 (AST) 和表甲基-3-酸盐 (EGCG) 来对抗炎症性肠病 (IBD). 这些纳米载体改善肠道健康,减少炎症,并提高IBD治疗的口服生物可用性.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 免疫学 免疫学 免疫学
背景情况:
- 德克斯硫酸 (DSS) 诱导炎症性肠道疾病 (IBD).
- 阿斯塔克桑丁 (AST) 和表甲基-3-酸盐 (EGCG) 具有抗氧化和抗炎性质,但稳定性和生物可用性不佳.
- 用于IBD治疗的疏水生物活性化合物的口服输送仍然是一个挑战.
研究的目的:
- 开发双重营养性宏分子纳米颗粒,以增强AST和EGCG的传递,以对抗IBD.
- 为了创建能够向线粒体的纳米载体和对质反应药物释放的纳米载体.
- 为了评估这些纳米载体在体外和体内治疗IBD治疗的疗效.
主要方法:
- 通过曼尼赫反应,EGCG被用作墙壁材料,以创建封装AST的纳米载体.
- 纳米载体被设计用于线粒体向和对谷氨敏感释放.
- 在体外研究中评估了线粒体积累,反应性氧物种 (ROS) 消除和线粒体膜潜力.
- 在IBD小鼠体内研究评估了结肠长度,M2巨分化和肠道微生物群组成.
主要成果:
- 在实验室中,纳米载体显示增强了线粒体积累,有效地消除了ROS,并保留了线粒体膜潜力 (比自由AST/EGCG强1.5倍).
- 在体内,纳米载体治疗使IBD小鼠的结肠长度增加了51.29%,并促进了M2巨分化.
- 口服纳米载体有利于调节肠道微生物群组成.
结论:
- 双重营养纳米载体为口服输送像AST和EGCG这样的疏水生物活性化合物提供了一个有希望的策略.
- 这些纳米载体通过减少炎症和改善肠道健康,显示出缓解IBD的巨大潜力.
- 开发的纳米载体系统克服了强效IBD治疗药物的稳定性和生物可用性的限制.
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