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健康的植物性饮食与通过改善代谢状态和器官功能来降低2型糖尿病风险有关:一项前性队列研究
Alysha S Thompson1, Catharina J Candussi2, Anna Tresserra-Rimbau3
1The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Northern Ireland, United Kingdom.
一种健康的植物性饮食可以通过改善身体脂肪,血糖,炎症和器官功能来显著降低2型糖尿病 (T2DM) 风险. 然而,不健康的植物性饮食会通过增加腰围和BMI等因素增加T2DM风险.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 植物性饮食因其对环境的好处和与降低2型糖尿病 (T2DM) 风险的关联而越来越被认可.
- 调查潜在的机制对于理解这种保护作用至关重要.
研究的目的:
- 探索将植物性饮食与T2DM风险降低联系在一起的潜在机制.
- 分析健康 (hPDI) 和不健康 (uPDI) 植物性指数与T2DM风险之间的关联.
主要方法:
- 利用了英国生物银行队列研究 (n=113,097) 的前性数据.
- 采用多变量考克斯回归和因果调解分析来评估T2DM风险和调解因素.
- 对40-69岁的参与者进行了12年的随访.
主要成果:
- 最高的hPDI四分位数与24%的T2DM风险降低有关,其介导者是较低的BMI,腰围,HbA1c和甘油三.
- 较高的UPDI分数与37%的T2DM风险增加相关,腰围,BMI和甘油三酸的增加为中介.
- 观察到各种心脏代谢风险因素具有显著的调解作用.
结论:
- 健康的植物性饮食似乎通过改善身体成分和代谢标志物来保护T2DM.
- 机制包括减少身体脂肪,更好地控制血糖,降低炎症,改善和肝功能.
- 强调健康的植物性食品的饮食模式对于T2DM预防至关重要.
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