聚烯微塑料通过肠道屏障功能障碍和C5a/C5aR通路激活诱导损伤
Yiran Liang1, Donghui Liu2, Jing Zhan2
1College of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, Beijing, 100193, People's Republic of China; College of Chemistry and Biological Engineering, University of Science and Technology Beijing, No. 30, Xueyuan Road, Beijing, 100083, People's Republic of China.
Environmental pollution (Barking, Essex : 1987)
|November 30, 2023
概括
聚烯微塑料 (PS-MPs) 危害肠道健康,导致小鼠损伤. 这种损伤涉及肠-轴和脏C5a/C5aR通路的激活,突出显示了严重的环境健康问题.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
背景情况:
- 微塑料 (MP) 是新兴的环境污染物,具有潜在的健康影响.
- 由MPs诱导的肠道两体平衡可以通过肠-轴影响脏健康.
- 将MP诱导的肠道静止和损伤联系在一起的机制在很大程度上仍未被探索.
研究的目的:
- 研究聚烯微塑料 (PS-MPs) 对脏健康的影响.
- 阐明PS-MPs诱导的损伤的潜在机制,专注于肠-轴.
- 确定补充C5a/C5aR通路在PS-MP的毒性中的作用.
主要方法:
- 用PS-MPs治疗小鼠,以评估对肠道屏障完整性和功能的影响.
- 使用抗生素混合物的肠道屏障恢复被用于评估其保护作用.
- 分析了尿中的C5a水平,中的C5aR表达和C5aR抑制剂 (PMX53) 的作用.
主要成果:
- PS-MPs 损害了肠道屏障,增加了尿路C5a和脏C5aR的表达,导致损伤症状.
- 抗生素治疗恢复了肠道屏障,缓解了损伤和调节C5a/C5aR通路标记物.
- 用PMX53抑制C5aR证实了其在PS-MPs诱导的损伤中的关键作用.
结论:
- 通过破坏肠道屏障并激活脏C5a/C5aR通路,PS-MPs在小鼠中诱导损伤.
- 肠-轴在微塑料诱导的损伤的发病过程中起着重要作用.
- 针对C5a/C5aR通路可能为微塑性相关脏疾病提供治疗策略.
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