对于保留的受孕产品,辅助生殖技术相关的风险因素
Seung Chik Jwa1, Hironori Takahashi2, Shunsuke Tamaru3
1Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan; Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan.
Fertility and sterility
|November 30, 2023
概括
在活产后保留的受孕产品与辅助生殖技术 (ART) 有关. 在冷解胚胎移植 (FETs) 中的激素替代周期显著增加了这种风险,突出了改善ART结果的关键因素.
科学领域:
- 生殖医学 生殖医学
- 产科和妇科 产科和妇科
- 临床流行病学临床流行病学
背景情况:
- 保留的受孕产物 (RPOC) 可以导致母亲的并发症.
- 辅助生殖技术 (ART) 涵盖了各种帮助怀孕的程序.
- 了解RPOC的ART特异性风险对于患者安全至关重要.
研究的目的:
- 通过辅助生殖技术 (ART) 怀孕的活产后,与保留的受孕产物 (RPOC) 相关的风险因素的识别.
- 具体评估与新鲜和冷解胚胎移植 (FET) 周期相关的风险.
主要方法:
- 这是一项回顾性队列研究,利用日本在2007年至2017年期间在ART后的369,608个独生子活产的注册数据.
- 分析重点是循环特定的数据,以确定RPOC风险因素的赔率比率和置信区间.
- 新鲜和FET循环之间的比较,包括对各种临床条件的子组分析.
主要成果:
- 在ART分娩中,RPOC发生在0.04%,其中92.4%来自FET周期.
- 在RPOC病例中,阴道分娩和胎盘增殖谱更常见.
- 在FET周期中,激素替代疗法 (HRT) 是最大的风险因素 (aOR 4.9),其次是胚胎阶段和辅助化.
- 卵细胞检索增加是新生周期的危险因素.
结论:
- 在ART治疗后的大多数RPOC病例与冷解胚胎移植 (FET) 有关.
- 在FET周期中使用激素替代疗法 (HRT) 是RPOC的重要风险因素.
- 这些发现强调了在基于HRT的FET周期中需要谨慎管理,以减轻RPOC风险.
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