皮层厚度的改变和系统性炎症定义了长期COVID患者的认知障碍
Bianca Besteher1, Tonia Rocktäschel1, Alejandra P Garza2
1Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany; German Center for Mental Health (DZPG), Germany; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Halle-Jena-Magdeburg, Germany.
Brain, behavior, and immunity
|November 30, 2023
概括
长期COVID患者表现出渐进的皮质厚度变化和明显的免疫变化,特别是那些有认知障碍的人. 这些发现凸显了对后COVID疾病的分组特异性治疗的需要.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID表现出各种症状,表明潜在的病理生理学差异.
- 初步证据表明,在特定的长期COVID患者群体中,有明显的脑结构和炎症变化.
研究的目的:
- 调查长期COVID患者子组之间的皮质厚度和外周免疫特征的差异.
- 为了比较健康对照组,康复的COVID-19幸存者和长期COVID患者与没有认知障碍之间的这些变化.
主要方法:
- 利用3台特斯拉MRI扫描进行基于表面的形态测量来分析皮质厚度.
- 在外周血液中测量了标志性炎症标志物.
- 包括120名参与者:健康对照组,COVID-19幸存者和长期COVID患者 (通过MoCA查具有/没有认知障碍).
主要成果:
- 从健康个体到长期COVID患者的认知缺陷,发现皮质厚度的连续增加.
- 在长期COVID患者中,皮层变化最为明显,这些患者有认知障碍 (MoCA <26).
- 在长期COVID患者中观察到IL-10,IFNγ和sTREM2水平升高,特别是在认知障碍患者中.
结论:
- 在COVID-19幸存者中持续存在的皮层和免疫学变化,在受损子组中具有明显的模式.
- 这些发现表明长期COVID的复杂病理机制.
- 强调需要对特定子组进行生物学研究,以开发有针对性的治疗方法.
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