在多发性骨髓瘤中使用仿真抗原受体T细胞疗法之前的桥梁治疗
1Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
British journal of haematology
|November 30, 2023
概括
桥梁疗法对于接受收养T细胞治疗复发性多发性骨髓瘤 (MM) 患者至关重要,因为制造时间长. 这一观点讨论了为重度预治疗的MM患者选择最佳的桥梁治疗方案.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 自主采用T细胞疗法,包括嵌合抗原受体T细胞 (CAR T) 疗法,已经改变了复发性多发性骨髓瘤 (MM) 治疗.
- 目前的制造工艺导致了相当大的静脉到静脉的时间,大多数患者需要桥梁治疗.
研究的目的:
- 概述一种在复发性MM中自主CAR-T细胞疗法之前选择最佳桥梁疗法的方法.
- 为了解决严重预治疗患者的桥梁治疗决策的复杂性.
主要方法:
- 这是一篇观点文章,而不是临床试验.
- 作者讨论了他们的临床考虑和决策过程,以弥合治疗选择.
主要成果:
- 桥梁治疗的选择是复杂的,并且是针对患者的.
- 考虑因素包括疾病负担,先前的治疗方法和患者的健康状况.
结论:
- 选择最佳的桥接疗法对于在等待CAR T细胞输液时保持疾病控制至关重要.
- 对于接受T细胞治疗的重度预治疗的复发性MM患者,需要采用量身定制的方法.
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