利用河流和废水作为SARS-CoV-2监测工具,在有限的正式污水系统的环境中使用
Kayla G Barnes1,2,3,4, Joshua I Levy5, Jillian Gauld6
1Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi. Kayla.Barnes@lstmed.ac.uk.
Nature communications
|November 30, 2023
概括
在马拉维对SARS-CoV-2的废水监测提供了早期检测COVID-19波和变体,超过了有限的临床测试. 这种方法为低资源环境中的病原体监测提供了一个至关重要的早期预警系统.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生监督是对公共卫生的监督.
- 病毒学 病毒学
背景情况:
- 随着COVID-19的爆发,人们越来越需要有效的全球健康监测.
- 废水监测是有价值的,但在低收入国家未得到充分利用.
- 马拉维对基于社区的COVID-19测试能力有限.
研究的目的:
- 评估在马拉维对SARS-CoV-2的废水监测的有用性.
- 通过环境监测来识别时间趋势和流通变异.
- 在资源有限的环境中建立传染病早期预警系统.
主要方法:
- 从2020年5月到2022年5月,从马拉维的河流和废水场所收集了水样.
- 使用分子方法在环境样本中检测到SARS-CoV-2RNA.
- 从阳性样本中测序病毒RNA,以识别循环变异.
主要成果:
- 在8.3%的环境水样中检测到SARS-CoV-2.
- 污水检测峰值之前临床病例峰值.
- 测序确定了Beta,Delta和Omicron变体,而Delta和Omicron的检测时间早于患者.
结论:
- 废水监测有效监测低资源环境中的SARS-CoV-2趋势和变体.
- 环境监测为新出现的传染病浪潮提供了早期预警系统.
- 这种方法可以提高在临床监测基础设施有限的国家的公共卫生能力.
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