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脊髓灰质炎病毒F17蛋白对抗线粒体编排的抗病毒反应

Nathan Meade1, Helen K Toreev1, Ram P Chakrabarty2

  • 1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Nature communications
|November 30, 2023
PubMed
概括

毒杆病毒操纵线粒体以逃避免疫检测. F17蛋白破坏了线粒体的变化,阻断了抗病毒反应,并通过向cGAMP合成酶 (cGAS) 和糖解来实现病毒复制.

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