在全国范围内,人口队列研究中的长期COVID的真实患病率
Claire E Hastie1, David J Lowe1,2, Andrew McAuley3,4
1School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Nature communications
|November 30, 2023
概括
估计长期COVID的患病率需要考虑背景症状. 经过调整后,归因于SARS-CoV-2感染的症状的调整流行率在6个月后为6.6%.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 长期COVID患病率的估计有所不同,需要考虑可能独立于SARS-CoV-2感染发生的症状.
- 准确地将症状归因于之前的SARS-CoV-2感染对于了解长期COVID的真正负担至关重要.
研究的目的:
- 为了确定特别归因于SARS-CoV-2感染的症状的流行率.
- 为了考虑大量人口队列中的背景症状率和潜在的混因素.
主要方法:
- 对198,096名苏格兰成年人进行了一项全国性人口队列研究.
- 参与者包括具有实验室确认的SARS-CoV-2感染症状的个体和从未感染过的个体的年龄,性别和社会经济匹配的对照组.
- 感染后6个月,12个月和18个月评估了症状发病率,并对混因素进行了统计调整.
主要成果:
- 在6个月后,64.5%的感染者报告了症状,而从未感染的群体中,这一比例为50.8%.
- 归因于SARS-CoV-2感染的症状的粗略流行率在6个月后为13.8%.
- 由于SARS-CoV-2感染而导致的症状的调整后流行率为6个月后6.6%,12个月后6.5%,18个月后10.4%.
结论:
- 长期COVID的症状是多样化的,通常是非特异性的,味道和气味的改变是显著的例外.
- 由于重叠的非特异性症状,在将症状归因于之前的SARS-CoV-2感染时必须小心.
- 根据背景率和混因素进行调整,可以更准确地估计长期COVID的流行率.
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