Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Aging01:26

Aging

56
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
56
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Mitochondria01:37

Mitochondria

13.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.3K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

119
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
119
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Model Analysis of the American Heart Association's Life's Essential 8: Can Physical Activity Mitigate Cardiovascular Risk Among Low-Income Individuals?

Journal of the American Heart Association·2026
Same author

Age-related differences in the skeletal phenotype of Brown Norway rats induced to develop chronic kidney disease.

Bone·2026
Same author

Semaglutide, at a dose that produces modest weight loss, induces mild suppression of bone remodeling in healthy control rats and those with chronic kidney disease.

Bone·2026
Same author

Radiomics identifies distinct cortical bone texture alterations in patients with CKD using HR-pQCT.

Bone research·2026
Same author

Determining Physical Function Measures for Estimating VO<sub>2</sub>Peak in Patients Receiving Hemodialysis.

Kidney medicine·2026
Same author

Mise à jour technique n° 466 : Soins virtuels pour la consommation de substances pendant la grossesse et en post-partum.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Peripheral B-cell receptor repertoire predicts immune-related adverse events following immune checkpoint inhibitor therapy in advanced renal cell carcinoma.

Scientific reports·2026
Same journal

Effects of black soldier fly (Hermetia illucens L.) larvae zoocompost on the mineral element content of blue honeysuckle berries.

Scientific reports·2026
Same journal

Investigation on absorption refrigeration performance of R1243zf with imidazolium ionic liquid as the working pairs.

Scientific reports·2026
Same journal

DeepTriage-CN: integrating clinical text with vital signs for emergency department admission prediction in an aging population.

Scientific reports·2026
Same journal

Gold nanoparticles as dual-action antiviral agents: disruption of SARS-CoV-2 viral envelopes and RNA integrity.

Scientific reports·2026
Same journal

Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance.

Scientific reports·2026
查看所有相关文章

相关实验视频

Updated: Jul 9, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K

在健康的衰老中,klotho与身体功能之间的关系.

Eliott Arroyo1,2, Cecilia A Leber1,3, Heather N Burney4

  • 1Division of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Scientific reports
|November 30, 2023
PubMed
概括
此摘要是机器生成的。

血清Klotho水平随着年龄的增长而下降,即使在健康的成年人中也是如此,在明显下降之前可能会影响身体功能. 这项针对健康成年人的研究表明,克洛托的衰退始于中年.

更多相关视频

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.6K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.4K

相关实验视频

Last Updated: Jul 9, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.6K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.4K

科学领域:

  • 老年学是一门学科.
  • 生物化学 生物化学
  • 运动生理学 运动生理学

背景情况:

  • 流行病学研究将循环的Klotho与身体功能联系起来,主要是患有并发症的老年人.
  • 之前的研究并没有关注Klotho与不同年龄组的健康,社区生活的成年人身体功能之间的关系.

研究的目的:

  • 为了研究血清Klotho水平与健康成年人队列中的身体功能之间的关联.
  • 确定克洛托水平是否在不同年龄组之间存在差异,并与特定的身体性能指标相关.

主要方法:

  • 一项涉及80名年龄在20-85岁之间的健康成年人的横截面研究.
  • 在四个年龄组 (20-34,35-49,50-64,≥65岁) 中测量和分析了血清克洛托水平.
  • 使用握力,椅子站测试和6分钟步行测试 (6MWT) 来评估身体功能.

主要成果:

  • 与20-34岁组相比,50-64岁和≥65岁年龄组的血清Klotho水平明显较低.
  • 在体能较低和体能较高的人之间,没有发现Klotho水平的显著差异.
  • 65岁或以上的年龄组与20-34岁的年龄组相比,显示6MWT距离较短.
  • 克洛托水平与年龄和体脂百分比有负相关性,与6MWT距离有正相关性.

结论:

  • 循环Klotho水平随着年龄的增长而下降,在健康的成年人中最早在第五个十年开始.
  • 这种下降可能会在可观察到的与年龄相关的运动能力下降之前发生.
  • 克洛托与年龄和身体功能的关联需要在年轻和中年人群中进行进一步的研究.