动脉样硬化和糖尿病对心血管疾病风险的综合影响
Jing Wang1, Ming-Jie Yin2, Jun-Wei Zheng3
1Medical Informatics Center, Peking University, Beijing, 100191, China.
Internal and emergency medicine
|November 30, 2023
概括
心血管疾病 (CVD) 的风险随着动脉样硬化和糖尿病的增加而增加. 动脉样硬化和糖尿病的综合作用显著地提高了心血管疾病的风险,比单独的任何一种疾病都要多,这凸显了针对性预防的必要性.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球疾病和死亡的主要原因.
- 动脉样硬化和糖尿病是心血管疾病的重要危险因素,具有复杂的相互作用.
- 动脉样硬化和糖尿病对心血管疾病发展的综合影响仍然不完全理解.
研究的目的:
- 研究动脉样硬化和糖尿病对患心血管疾病 (CVD) 的风险的联合影响.
- 量化与动脉样硬化,糖尿病及其并发性疾病相关的心血管疾病风险增加.
- 为高风险人群提供针对心血管疾病的初级预防策略提供证据.
主要方法:
- 这是一项从2010年1月到2020年12月期间涉及59,268名亚洲参与者的队列研究.
- 数据收集包括人体测量,生化和流行病学信息,以及手腕关节脉冲波速度 (baPWV) 测试.
- 考克斯比例危险回归和分发危险模型被用于分析心血管疾病风险,并进行了灵敏度分析.
主要成果:
- 心血管疾病的累积发病率在动脉样硬化和糖尿病 (25.59%) 的组中最高.
- 与健康对照人群相比,糖尿病,动脉样硬化和并发症患者的风险显著增加 (HR分别为1.88,1.40和2.10).
- 患有心力衰竭和中风等特定心血管疾病事件的风险在患有两种疾病的患者中明显高于仅患有一种疾病的患者.
结论:
- 动脉样硬化和糖尿病都会独立增加心血管疾病 (CVD) 的风险.
- 动脉样硬化和糖尿病的共存显著放大了CVD风险,超出了每个疾病的附加效应.
- 综合管理和初级预防策略对于患有并发性动脉样硬化和糖尿病的人来说至关重要,以减轻心血管疾病负担.
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