作为生物标记物的氧和植物:当前状态和未来前景
Vesa M Olkkonen1,2, Helena Gylling3
1Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland. vesa.olkkonen@helsinki.fi.
Advances in experimental medicine and biology
|November 30, 2023
概括
氧醇和植物醇作为疾病和胆固醇吸收的生物标志物具有前景. 标准化分析方法和高吞吐量平台是必要的,因为它们的常规临床使用.
科学领域:
- 生物化学 生化学
- 临床化学 临床化学
- 生物标志物发现发现
背景情况:
- 氧醇和植物醇是健康个体中低水平发现的固醇化合物.
- 新出现的证据表明,它们有潜力作为各种疾病和胆固醇吸收的生物标志物.
- 目前的研究往往涉及小群体,限制了常规生物标志物应用.
研究的目的:
- 突出氧醇和植物醇作为疾病和胆固醇吸收生物标志物的潜力.
- 确定这些固醇作为生物标志物的常规临床使用的要求.
- 强调对标准化分析方法和高通量平台的需求.
主要方法:
- 对氧醇和植物醇生物标记物应用现有文献的综述.
- 讨论分析挑战和日常使用的要求.
- 探索植物醇作为胆固醇吸收和动脉样硬化心血管疾病 (ASCVD) 风险的标志物.
主要成果:
- 氧醇显示出作为心血管,神经退行性疾病和癌症的生物标志物的潜力.
- 植物醇是胆固醇吸收的有价值标记物.
- 分析方法的标准化和高通量平台的开发对于常规生物标志物使用至关重要.
结论:
- 氧醇和植物醇作为临床生物标志物具有显著的前景.
- 大规模的前性队列研究和标准化,高通量分析方法对于它们的广泛采用至关重要.
- 建议将胆固醇代谢查纳入ASCVD风险评估,特别是在高风险人群中.
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