一个新的统计工作流 (基于R包) 来调查一个感兴趣的变量与代谢组之间的关联
Paola G Ferrario1, Achim Bub2, Lara Frommherz3
1Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Haid-und-Neu-Str. 9, 76131, Karlsruhe, Germany. paola.ferrario@mri.bund.de.
Metabolomics : Official journal of the Metabolomic Society
|November 30, 2023
概括
本研究引入了用于代谢学数据分析的开源统计工作流,简化了对代谢物-特征关联的识别. 强大的基于R包的工作流确保了复杂数据集的清晰结果可视化.
科学领域:
- 代谢学 代谢学 代谢学
- 生物信息学是一种生物信息学.
- 统计遗传学 统计遗传学
背景情况:
- 在代谢学研究中,研究代谢组与特征的关联是至关重要的.
- 对复杂的代谢学数据的统计分析带来了重大挑战.
- 需要强大的统计工具来进行可靠的验证和清楚地呈现结果.
研究的目的:
- 开发一个开源的统计工作流来分析代谢学数据.
- 为了解决代谢学数据集的内在复杂性和异质性.
- 提供一个广泛适用的工具,用于代谢学中的统计分析.
主要方法:
- 集成专门的R包,设计用于异质代谢学数据.
- 处理各种代谢物参数,包括不同的矩阵,分析平台和测量精度.
- 适应有针对性和非有针对性的方法,多样化的缩放,异质的差异,相关性,缺失值和不完整的数据.
主要成果:
- 一个自由可用的,完全共享的R代码工作流.
- 输出包括与感兴趣的特征相关的代谢物表和可视化图.
- 在两个独立的数据集上验证了工作流,证明了实用性和稳定性.
结论:
- 统计工作流提供了证明的稳定性和对代谢学数据分析的好处.
- 该工具对于研究人员来说很容易重复使用,他们分析自己的代谢学数据集.
- 促进了新陈代谢-特征关联的清晰呈现和弹性验证.
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