在养老院使用潜在不合适的精神药物:一项意大利观察性研究
Marina Azab1, Alessio Novella2, Aladar Ianes3
1Laboratory of Clinical Pharmacology and Appropriateness of Drug Prescription, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy. marina.azab@marionegri.it.
Drugs & aging
|November 30, 2023
概括
这项研究发现,不同的标准识别了在养老院居民中潜在不适当的精神药物使用的不同率. 在不适当的精神药物使用和死亡率之间没有发现任何关联.
科学领域:
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 老年人,尤其是养老院的老年人,经常有多种慢性疾病 (多病症),并处方多种药物 (多种药物).
- 潜在的不适当的药物使用,特别是精神药物,在养老院居民中很常见.
- 医生在为有复杂健康需求的老年患者选择最佳药物时面临着挑战.
研究的目的:
- 通过使用Beers,STOPP/START和FORTA标准,检查养老院居民中潜在不适当的精神药物使用的流行情况.
- 调查潜在不适当的精神药物使用与该人口中的死亡率之间的联系.
主要方法:
- 在27个意大利长期护理养老院进行了回顾性横截面队列研究.
- 对65岁及以上居民的潜在不适当的精神药物使用的患病率是使用Beers,STOPP/START和FORTA标准计算的.
- 单变量和多变量分析检查了不适当的精神药物使用和死亡率之间的关系,控制年龄,性别和并发症.
主要成果:
- 在2555名居民中,74.7%接受了精神药物. 潜在的不适当使用因标准而异:FORTA (7.3%),酒 (63.2%) 和STOPP/START (56.8%).
- 比尔斯和STOPP/START标准发现,与FORTA相比,暴露于可能不合适的精神药物的患者比例更高.
- 在单变量或多变量分析中,在潜在不适当的精神药物使用和死亡率之间没有发现相关性.
结论:
- 标准的选择显著影响了在养老院居民中潜在不适当的精神药物使用的估计流行率.
- 酒和STOPP/START标准发现了比FORTA标准更多的潜在不适当的精神药物使用.
- 目前的证据不支持潜在的不适当的精神药物使用和老人院人口的死亡率之间的联系.
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