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新生儿早发性败血症导致的死亡风险因素:一项回顾性队列研究
Xinhong Chen1,2,3,4,5, Huayun He1,2,3,4,5, Hong Wei1,2,3,4,5
1Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China.
BMC infectious diseases
|November 30, 2023
概括
新生儿早期性败血症 (EOS) 与显著的死亡率有关. 死亡的主要危险因素包括出生体重,肺高血压,败血症,心力衰竭,血清乳酸和AST水平. 解决这些问题可以改善结果.
科学领域:
- 新生儿医学 新生儿医学
- 儿童传染病 儿童传染病
- 临床流行病学临床流行病学
背景情况:
- 早发性败血症 (EOS) 对新生儿死亡率构成重大威胁.
- 确定EOS死亡率的预测因素对于及时干预至关重要.
研究的目的:
- 确定传统实验室检测结果与患有EOS的婴儿死亡率之间的联系.
- 为了确定特定的风险因素,有助于死亡的新生儿诊断EOS.
主要方法:
- 在2020年1月至2021年8月期间进行了一项回顾性病例控制研究.
- 患有EOS的婴儿被分为非幸存者和幸存者组.
- 使用了统计分析,包括单变量,ROC曲线和多变量逻辑回归.
主要成果:
- 在556名新生儿中,38名 (6.8%) 死亡.
- 在幸存者和非幸存者之间观察到出生体重,败血症休克,心力衰竭,肺高血压,血清乳酸和AST水平的显著差异.
- 多变量分析确定了出生体重,PPHN,败血症休克,心力衰竭,血清乳酸和AST作为死亡的独立风险因素.
结论:
- 出生体重,PPHN,败血症,心力衰竭,血清乳酸和AST是影响EOS预后的重要因素.
- 早期识别和管理这些可修改的风险因素可能会降低新生儿死亡率.
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