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Updated: Jul 9, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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针对表皮生长因子受体,在皮层脑损伤中招募新产生的神经细胞

Ricardo Gómez-Oliva1,2, Noelia Geribaldi-Doldán2,3, Samuel Domínguez-García1,2,4

  • 1Área de Fisiología, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain.

Journal of translational medicine
|December 1, 2023
PubMed
概括

大脑损伤会触发神经发生,但神经芽细胞无法到达损伤部位. 抑制TGF-α/EGFR通路促进神经细胞迁移,提供一种潜在的大脑再生策略.

关键词:
成年人的神经发生.大脑受伤的原因神经细胞迁移的迁移神经再生是一种神经再生.转化生长因子α的转化生长因子α.

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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury11:57

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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