维他诺化物和BACOSIDE A负载的proniosomes的表征:对动物模型中氧化应激和高重力下的生存的影响
Yallappa B Saunshi1, Corbon Godfrey David2, Heartwin A Pushpadass3
1Department of Biochemistry, Jain University, Bengaluru, India.
Drug development and industrial pharmacy
|December 1, 2023
概括
载有维他诺化物和化物A的proniosomes证明了持续的药物释放,有效地保护血脑屏障 (BBB) 免受氧化应激,并提高了大鼠在超重力条件下的生存率.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 生物技术是生物技术.
背景情况:
- 氧化应激可以破坏血脑屏障 (BBB),影响神经功能.
- 超重力给生理系统带来了额外的挑战,包括BBB.
- 维他诺化物和BACOSIDE A是具有潜在治疗功能的天然化合物.
研究的目的:
- 为了表征维他诺化物和巴科西德A的前基因组.
- 评估这些proniosomes在保护氧化应激诱导的BBB损伤方面的有效性.
- 在大鼠模型中评估它们在超重力条件下的保护作用.
主要方法:
- 通过薄膜水化,使用维他诺化物 (来自*W. somnifera*) 和化物A (来自*B. monnieri*) 制备了proniosomes.
- 研究了体外药物释放动力学.
- 在Wistar Albino大鼠的体内研究评估了抗氧化酶活性,BBB完整性 (埃文斯蓝色外流) 和在模拟超重力条件下的生存率.
主要成果:
- 普罗尼奥索姆在9个小时内持续释放维他诺化物和巴科赛德A.
- 在血和大脑中观察到抗氧化酶活性显著增加.
- 药物载荷的proniosomes最小化了埃文斯蓝色染料的扩散,表明BBB完整性得到保护.
- 与对照组 (50%) 相比,接受治疗的老鼠 (75-83.3%) 在超重力的生存率更高.
结论:
- 基因组合使药物持续释放成为可能.
- 这种输送系统有效地保护血脑屏障的完整性免受氧化损伤.
- 在超重力条件下,Proniosomes提高了生存率.
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