合成CT用于肺适应性放射治疗的准确性和可行性:一个幻影研究
Ruifeng Zhao1, Xingliu Wang2, Huanhai Wei1
1Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Technology in cancer research & treatment
|December 1, 2023
概括
肺适应性放射治疗中的呼吸系统变化导致剂量不一致. 来自Velocity的合成CT显示了对解剖学和剂量测量准确性的承诺,但振幅变化会影响准确性.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 医疗成像医学成像
背景情况:
- 肺部放射治疗期间的呼吸运动导致计划和输送剂量之间的差异.
- 调查微小的断片间振幅变化对肺适应性放射治疗中剂量递送精度的影响至关重要.
研究的目的:
- 评估使用肺适应性放射治疗的Velocity程序生成的合成计算机断层扫描 (sCT) 的几何和剂量准确性.
- 评估分数间振幅变化对sCT精度的影响.
主要方法:
- 使用计算机成像参考系统幻影模拟了微小的分数间振幅变化.
- 通过使用Velocity程序规划四维计算机断层扫描 (4D-CT) 生成的sCT.
- 与4D-CT相比,对sCT进行了几何和剂量测量评估.
主要成果:
- 与kV圆束CT (83.9%的HU差异) 相比,sCT显示了更好的图像质量和精度 (22.3%的HU差异).
- 速度程序有效地处理正常的呼吸模式,剂量-体积组图与4D-CT. 密切匹配.
- 显著的断片间振幅变化将获得100%处方剂量的体积减少到sCT的59.6%.
结论:
- 由Velocity生成的sCT紧密模仿真实患者的解剖学和剂量,使肺适应性放射治疗成为可能.
- 虽然对于常规运动是有效的,但sCT的准确性随着实质性的断片间振幅变化而减少.
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