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脑麻患者和典型发育个体之间的肌肉大小和力量的年龄相关差异

Mattie E Pontiff¹, Noelle G Moreau¹

¹Department of Physical Therapy, LSUHSC-New Orleans, New Orleans, LA, USA.

Physical & occupational therapy in pediatrics

|December 1, 2023

概括

肌肉大小和力量随着年龄的增长在脑 (CP) 和典型发育 (TD) 两组. 然而,与TD个体相比,患有CP的个体相对于体重的增强速度较慢.

科学领域:

神经学神经学
人体生理学人体生理学
发展生物学发展生物学

背景情况:

大脑 (CP) 影响运动功能和肌肉发育.
了解肌肉质量和力量的年龄相关变化对于管理CP至关重要.
之前的研究还没有完全阐明与典型发育同龄人相比,CP患者的膝盖延伸肌肉的特定与年龄相关的轨迹.

研究的目的:

为了研究和比较与年龄相关的膝关节延伸肌的大小和强度的差异.
分析CP和典型发育 (TD) 个体的肌肉体积,强度和年龄之间的关系.
确定这些群体之间与增长相关的力量发展的潜在差异.

主要方法:

包括54名CP患者 (年龄14.5±4.5岁,GMFCS I-V) 和33名TD患者 (年龄16.2±5.5岁).
使用线性回归和ANCOVA来检查直骨 (RF) 和大侧 (VL) 肌肉体积,异动力膝盖延伸器强度和年龄之间的关系.
在CP和TD组之间比较与年龄相关的差异和回归斜率.

主要成果:

肌肉体积在TD (VL:r2=0.48,RF:r2=0.56) 和CP组 (VL:r=0.36,RF:r2=0.27) 均显示出与年龄相关的统计学上显著的增加,而回归斜率在两组之间没有显著差异.
在TD (r2=0.66) 和CP (r2=0.096) 两组中都观察到与年龄相关的显著强度差异.
然而,与年龄相关的力量差异的斜率在CP组与TD组相比显著较低 (p < .001).

结论:

肌肉体积和肌肉强度都表现出与年龄相关的线性增加,患者有CP和TD.
与TD个体相比,患有CP的个体表现出与年龄相关的膝盖延伸肌肉强度和强度对身体质量比的线性斜率显著降低.
这表明,CP患者的肌肉力量可能无法充分跟上生长过程中体重的增加,这可能会影响功能能力.

关键词:

年龄化衰老衰老与年龄相关的疾病.肌肉结构肌肉架构肌肉架构肌肉的力量肌肉的力量肌肉的力量肌肉体积肌肉体积肌肉体积肌肉体积

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