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在患有固体瘤的患者中,变异性等位基因频率和平均瘤分子与瘤负担之间的相关性

Ekaterina Kalashnikova1, Vasily N Aushev1, Allyson Koyen Malashevich1

  • 1Natera, Inc., Austin, TX, USA.

Molecular oncology
|December 1, 2023
PubMed
概括

循环瘤DNA (ctDNA) 水平,以平均瘤分子 (MTM) /毫升和平均变异异位基因频率 (mVAF) %来衡量,正相关. 在ctDNA动态的变化,特别是MTM/ml,显著预测免疫治疗的转移性患者的无进展生存率.

关键词:
生物标志物 生物标志物在循环中的瘤DNA.这意味着瘤分子.变异性等位基因的频率变异

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