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准备好的MW-免疫敏感剂精确释放NO以降低HIF-1α表达的调节,并增强免疫细胞死亡

Wenna Guo^1,2, Zengzhen Chen², Qiong Wu²

¹School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|December 1, 2023

概括

这项研究介绍了GaMOF-Arg-TPP,这是一种创新的材料,可以产生氧化 (NO),以防止微波热疗法 (MWTT) 后癌症转移和复发. 这种方法通过提高热敏度和免疫反应来提高瘤治疗的疗效.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
癌症治疗癌症治疗

背景情况:

微波热疗法 (MWTT) 由于癌症转移和复发率高,其临床应用有限.
氧化 (NO) 通过增强热敏度,减少缺氧诱导因子-1 (HIF-1) 和诱导免疫细胞死亡 (ICD) 来减轻这些问题.

研究的目的:

设计和合成新的MW免疫敏感剂,用于增强癌症治疗.
研究这些药物在预防MWTT后瘤转移和复发方面的疗效.

主要方法:

开发GaMOF-Arg-TPP,一种基于的金属有机框架,载有L-氨酸 (L-Arg),并与向线粒体的三 (TPP) 相结合.
在小鼠体内给予GaMOF-Arg-TPP,然后进行MW照射.
评估NO生成,HIF-1表达,瘤缺氧,免疫细胞死亡标志物 (CRT,HMGB1),T细胞增殖和治疗结果.

主要成果:

在MW辐射下,GaMOF-Arg-TPP产生了NO,释放了L-Arg并与ROS反应.
NO有效降低HIF-1的调节,缓解MW诱导的瘤缺氧.
观察到增强的免疫反应,包括增加卡莱蒂库林 (CRT) 暴露,高流动性组盒子1 (HMGB1) 释放和T细胞增殖.
NO还诱导线粒体损伤,增加对MWTT的敏感性,从而防止瘤转移和复发.

结论:

在癌症治疗中,GaMOF-Arg-TPP作为一种有效的MW-免疫敏感剂.
这种利用金属有机框架的新方法在预防瘤转移和复发方面显示出前景,为癌症治疗提供了一种有效的策略.

关键词:

缺氧诱导因子-1-1 免疫性细胞死亡免疫性细胞死亡微波热疗法微波热疗法氧化氧化是一种氧化.

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