在全膝关节置换过程中通过外围神经阻塞进行麻醉,对老年患者的术后炎症没有影响
Bin Lu1,2, Jianwen Jin3, Shujun Pei2,4
1Department of Anesthesiology, Xi'an Chang'an District Hospital, Xi'an, China.
Journal of orthopaedic surgery (Hong Kong)
|December 1, 2023
概括
在接受全膝关节置换 (TKR) 的老年患者中,外围神经阻塞 (PNB) 不会减少压力或炎症,但与全身麻醉 (GA) 相比,显著减少术后并发症,特别是呼吸问题和恶心/吐.
科学领域:
- 麻醉学 麻醉学
- 整形外科手术 整形外科手术
- 老年医学 老年医学
背景情况:
- 周围神经阻塞 (PNB) 之前在接受全膝关节置换 (TKR) 的老年患者中,与全身麻醉 (GA) 相比,恢复速度更快.
- 这项研究调查了PNB是否可以降低TKR患者的术后压力,炎症和术后并发症.
研究的目的:
- 为了确定外围神经阻塞 (PNB) 是否降低经过全膝关节置换 (TKR) 的老年患者的外科手术期间的压力和炎症.
- 评估PNB是否能降低老年患者TKR后术后并发症的发生率.
主要方法:
- 165名接受TKR的老年患者 (≥65岁) 被随机分配给接受GA或PNB.
- 主要结局通过血清标志物 (CRP,IL-6),ESR,WBC,中性粒细胞计数和血糖来测量外科手术期间的炎症和压力.
- 二次结局包括各种术后并发症,如心血管,呼吸道,肝脏/脏问题,失眠,妄想和恶心/吐.
主要成果:
- 虽然压力和炎症标记的时间点显示出统计学意义,但时间和组之间没有发现相互作用.
- 与GA组相比,PNB组的整体术后并发症发生率明显较低 (p = .006).
- 具体来说,手术后的呼吸道并发症 (p = .005) 和恶心/吐 (p = .040) 在 PNB 显著减少.
结论:
- 周围神经阻塞 (PNB) 不能减轻老年TKR患者的外科应激或炎症.
- 在全膝关节置换术后,PNB显著降低了术后并发症的发生率,特别是呼吸系统问题和恶心/吐.
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