制药在位凝治疗青光眼:最近的趋势和发展与最新的研究和专利
Rohitas Deshmukh1, Rajesh Singh1, Sakshi Mishra1
1Institute of Pharmaceutical Research, GLA University, Mathura 281406, India.
Critical reviews in therapeutic drug carrier systems
|December 1, 2023
概括
眼科 in situ 凝是一种优越的替代品,可以替代传统的眼滴,用于治疗青光眼. 这些"智能凝"可以改善药物输送和留在眼睛中的时间,从而提高治疗效果.
科学领域:
- 眼科医生 眼科 眼科
- 药品制造 药品制造 药品制造
- 生物材料科学 生物材料科学
背景情况:
- 玻璃眼瘤是一种渐进的视神经病变,导致视网膜质细胞缩,通常与眼内压力升高有关.
- 常规的眼滴治疗青光眼的挑战包括眼部生物可用性差,频繁的注射需要,以及患者的合规问题.
研究的目的:
- 审查眼科在位凝配方的机制和应用,以治疗青光眼的治疗.
- 为了突出 in situ 凝的优势,而不是传统的眼滴疗法.
- 讨论用于创建这些"智能"眼科系统的基于聚合物的创新策略.
主要方法:
- 对眼科现场凝配方治疗青光眼的现有文献的综述.
- 在in situ凝开发中使用的不同聚合物系统和触发器 (pH,温度,离子) 的分析.
- 在眼部施用时,讨论从sol到gel的相变机制.
主要成果:
- 在眼睛接触时,in situ凝从液体转化为凝,增长药物停留时间.
- 各种聚合物和激活机制使药物持续释放,提高治疗疗效.
- 这些"智能"凝提供了一个有前途的解决方案,以提高药物可用性和患者在青光眼治疗中的遵从性.
结论:
- 眼科 in situ 凝是通过提高药物的生物可用性和患者遵守性来优化青光眼治疗的有希望的策略.
- 对刺激反应性聚合物的进一步研究可以导致更有效,更为患者友好的青光眼治疗方法.
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