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Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice
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通过人类-CYP3A4-转基因小鼠模型对人类暴露的可预测性:一个元分析

David Damoiseaux1, Alfred H Schinkel2, Jos H Beijnen1,3

  • 1Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Clinical and translational science
|December 1, 2023
PubMed
概括

与传统的小鼠模型相比,表达人类CYP3A4酶的人性化小鼠模型并没有显著改善首次人体剂量预测. 进一步的药理动力学建模可能会提高这些人性化的模型的预测准确性.

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