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在糖尿病神经病变中研究昼夜节律基因Per3

Hüsniye Rüstemoğlu¹, Recai Aci², Süheyla Uzun³

¹Department of Medical Biology, Faculty of Medical, Tokat Gaziosmanpasa University, Tokat, Turkey.

Nucleosides, nucleotides & nucleic acids

|December 1, 2023

概括

这就是PER3基因.

科学领域:

遗传学是一个遗传学.
内分泌学在内分泌学.
神经学神经学

背景情况:

糖尿病神经病变 (DN) 是一种严重的糖尿病并发症,影响神经.
循环节律障碍与糖尿病和DN发育有关.
节律基因表达的变化可能会影响糖尿病的进展.

研究的目的:

研究PER3基因VNTR多态和DN之间的关联.
检查PER3在糖尿病及其并发症中的作用.

主要方法:

案例控制研究的设计.
包括84名糖尿病患者,220名DN患者和218名健康对照.
PER3可变数串联重复 (VNTR) 多态性分析.

主要成果:

在DN患者和对照人群中没有显著的PER3 VNTR多态差异.
糖尿病和对照组之间PER3 5/5基因型和5个等位基因的显著差异.
在患者组和对照组之间观察到显著差异 (p < 0.05).

结论:

PER3基因VNTR多态可能与糖尿病有关.
PER3基因 VNTR 多态性与糖尿病神经病变没有显著的关联.
这是研究PER3 VNTR多态性与DN和糖尿病相关的第一个研究.

关键词:

糖尿病糖尿病糖尿病在 PER3 中, PER3 是 PER3 的代码.糖尿病神经病变糖尿病神经病变在vNTRTR中使用.

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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...