细胞衰老和衰老剂:关于它们的作用和应用的最新更新
Lokesh Chandrakar1, Ramesh Ambatwar1, Gopal L Khatik1
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli, Uttar Pradesh, 226002, India.
Current topics in medicinal chemistry
|December 1, 2023
概括
细胞衰老是一种衰老的标志,涉及细胞循环停止和衰老细胞的积累. 老化剂,针对这些细胞的药物,在延缓衰老和治疗与年龄相关的疾病方面表现有前途.
科学领域:
- 老年学和细胞生物学.
- 药理学和治疗发展.
背景情况:
- 细胞衰老是一种不可逆转的细胞循环停止状态,由细胞压力因素引发,导致衰老和与年龄相关的疾病.
- 累积的衰老细胞 (SCs) 损害组织修复,并通过衰老相关分泌表型 (SASP) 促进炎症.
- 消除SCs已被证明可以延长寿命并延迟衰老过程.
研究的目的:
- 讨论老年化药物作为治疗与年龄有关的疾病和衰老的潜在疗法.
- 探索老化药在神经退行性疾病中的作用.
- 审查新兴的天然老化剂及其治疗潜力.
主要方法:
- 对遗传学研究的审查,关于SCs的去除和寿命延长.
- 讨论设计用于选择性SCs清除的老化小分子.
- 分析新兴的天然产品和改性类似物作为老化剂.
主要成果:
- 老化剂有选择地消除衰老细胞,为与年龄相关的疾病提供治疗潜力.
- quercetin,dasatinib,fisetin,piperlongumine和curcumin等天然产品表现出衰老的活性.
- 这些天然产品的改性类似物在临床前模型中显示出更好的选择性和疗效.
结论:
- 老化药物代表了一种有前途的治疗策略,用于对抗衰老和相关疾病.
- 针对细胞衰老具有治疗神经退行性疾病的潜力.
- 包括天然产品衍生品在内的老化药物的进一步开发可能会对老年医学产生重大影响.
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