内分泌核受体和长非编码RNA在癌症中的相互调节 (综述)
Monica Cantile1, Margherita Cerrone2, Maurizio Di Bonito2
1Scientific Directorate, National Cancer Institute INT‑IRCCS Fondazione G. Pascale, I-80131 Naples, Italy.
International journal of oncology
|December 1, 2023
概括
核受体 (NRs) 调节细胞功能,它们的失调有助于癌症. 本综述探讨了癌症生物标志物和治疗的NR和长非编码RNA相互作用.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 癌症研究 癌症研究
背景情况:
- 核受体 (NRs) 是正常细胞生理学必不可少的关键转录调节体.
- 通过突变或表观遗传变化,NRs的放松调节与人类疾病,特别是癌症有关.
- 国家基因组参与复杂的基因组网络,推动癌症的发展和进展.
研究的目的:
- 审查核受体 (NRs) 和长非编码RNAs (lncRNAs) 在各种癌症中的复杂相互作用.
- 根据NR-lncRNA相互作用来确定潜在的诊断生物标志物.
- 为癌症治疗提出针对这些相互作用的新型治疗策略.
主要方法:
- 文献综述侧重于研究核受体和癌症中非编码RNA的研究.
- 对基因组数据和NR-lncRNA交叉交互背后的分子机制的分析.
- 对瘤发生过程中NR介导的转录调节现有知识的综合.
主要成果:
- NRs是更大的转录网络的组成部分,受多个NRs和转录因子的影响.
- 非编码RNAs,包括microRNAs和lncRNAs,显著调节NR功能,反之亦然.
- 在不同瘤类型的癌症发病和进展中,NRs和lncRNAs之间的相互相互作用至关重要.
结论:
- NRs和lncRNAs之间的复杂相互作用为癌症病原体提供了新的见解.
- 准NR-lncRNA网络为开发新型癌症生物标志物和治疗干预提供了有希望的途径.
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