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Updated: Jul 9, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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基因素H4与Cse4的相互作用促进了Cse4的构造变化,从而促进了它的相和错位化

Kentaro Ohkuni1, Wei-Chun Au1, Amira Z Kazi1

  • 1Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Nucleic acids research
|December 1, 2023
PubMed
概括

错位CENP-A (中间体蛋白A) 导致染色体不稳定,并与癌症有关. 基因素H4相互作用诱导CENP-A的结构变化,促进其错位化,并提供了对癌症机制的见解.

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